고분자마이셀을 이용한 생리활성물질 전달체
고분자 하이드로젤을 이용한 방사선 표지자/유전자 전달체
고분자마이셀을 이용한 분자영상진단용 나노프로브
학력
1978 : 서울대학교 화학공학과 학사
1984 : KAIST 화학공학 박사
약력/경력
성균관대학교 공과대학 학장(2005 - 2007)
진단/치료용 고분자소재 연구센터 센터장(ERC)(2010 - )
한국공학한림원 회원(2007- ), 화학생명공학분과위원장(2015~ 2016)
한국과학기술한림원 정회원(2011- ), 국내협력부장(2016 ~ )
한국고분자학회 회장(2013)
학술지 논문
(2021)
Therapeutic effects of boronate ester cross-linked injectable hydrogels for the treatment of hepatocellular carcinoma.
BIOMATERIALS.
2021,
21
(2021)
Advances in biodegradable and injectable hydrogels for biomedical applications hydrogels for biomedical applications.
JOURNAL OF CONTROLLED RELEASE.
2021,
330
(2021)
Development of pH-Responsive Polymer Coating as an Alternative to Enzyme-Based Stem Cell Dissociation for Cell Therapy.
MATERIALS.
14,
491
(2021)
Alternative method for trypsin-based cell dissociation using poly (amino ester) coating and pH 6.0 PBS.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS.
36,
1
(2020)
Dual activatable self-assembled nanotheranostics for bioimaging and photodynamic therapy.
JOURNAL OF CONTROLLED RELEASE.
2020,
327
(2020)
Albumin affibody-outfitted injectable gel enabling extended release of urate oxidase-albumin conjugates for hyperuricemia treatment.
JOURNAL OF CONTROLLED RELEASE.
2020,
324
(2020)
A novel injectable pH–temperature sensitive hydrogel containing chitosan–insulin electrosprayed nanosphere composite for an insulin delivery system in type I diabetes treatment.
BIOMATERIALS SCIENCE.
2020,
8
(2020)
Intracellular delivery of cytochrome C using hypoxia-responsive polypeptide micelles for efficient cancer therapy.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.
2020,
111069
(2020)
Recent Advances of pH-Induced Charge-Convertible Polymer-Mediated Inorganic Nanoparticles for Biomedical Applications.
MACROMOLECULAR RAPID COMMUNICATIONS.
2000106,
1
(2020)
Recent Advances of pH-Induced Charge-Convertible Polymer-Mediated Inorganic Nanoparticles for Biomedical Applications.
MACROMOLECULAR RAPID COMMUNICATIONS.
2020,
2000106
(2020)
pH-Sensitive Polymeric Micelles as the Methotrexate Carrier for Targeting Rheumatoid Arthritis.
MACROMOLECULAR RESEARCH.
28,
2
(2020)
Modularly engineered alginate bioconjugate hydrogel as biocompatible injectable scaffold for in situ biomineralization.
CARBOHYDRATE POLYMERS.
2020,
233
(2020)
Highly potent intradermal vaccination by an array of dissolving microneedle polypeptide cocktails for cancer immunotherapy.
JOURNAL OF MATERIALS CHEMISTRY B.
2020,
8
(2019)
Hyaluronic acid decorated pH- and temperatureinduced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration.
NEW JOURNAL OF CHEMISTRY.
2019,
43
(2019)
Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma.
BIOMATERIALS.
2020,
230
(2019)
Green preparation of pH-responsive and dual targeting hyaluronic acid nanogels for efficient protein delivery.
EUROPEAN POLYMER JOURNAL.
2019,
121
(2019)
Smart injectable biogels based on hyaluronic acid bioconjugates finely substituted with poly(β-amino ester urethane) for cancer therapy.
BIOMATERIALS SCIENCE.
2019,
1
(2019)
Tumor acidity and CD44 dual targeting hyaluronic acid-coated gold nanorods for combined chemo- and photothermal cancer therapy.
CARBOHYDRATE POLYMERS.
2019,
226
(2019)
Multifunctional hyaluronic acid-mediated quantum dots for targeted intracellular protein delivery and real-time fluorescence imaging.
CARBOHYDRATE POLYMERS.
2019,
224
(2019)
Physically crosslinked injectable hydrogels for long-term delivery of oncolytic adenoviruses for cancer treatment.
BIOMATERIALS SCIENCE.
2019,
7
단행본
(2012)
"Block Copolymer Hydrogels" in Encyclopedia of Polymer Science and Technology.
Encyclopedia of Polymer Science and Technology.
공동
(2012)
Injectable Temperature- and pH/Temperature-Sensitive Block Copolymer Hydrogels" in Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, Xian Jun Loh and Oren Scherman Ed..
the Royal Society of Chemistry.
공동
(2008)
chapter7. pH and Temperature Sensitive Block Copolymer Hydrogels Based on Poly(ethylene glycol) and Sulfamethazine.
American Chemical Society.
주저자
특허/프로그램
pH 민감성 3차원 스캐폴드 제조방법 및 이를 이용한 세포배양용.
10-2016-0050258.
20171123.
대한민국
Albumin conjugated temperature and pH-sensitive multi-block copolymer, a method of preparation thereof and drug delivery system using the same.
14/574,720 .
20171010.
미국
Temperature and pH-sensitive Block Copolymer having Excellent Safety In Vivo and Hydrogel and Drug Delivery System using thereof.
12/676,828.
20160530.
미국
Temperature and pH-sensitive block copolymer and polymeric hydrogel using the same.
11 2006000685.
20160310.
독일
pH 민감성 고분자 마이셀을 이용한 MRI 조영제 제조방법 및 이용한 진단 및 치료를 위한 조영제/약물전달체.
2008-0089941 .
20160127.
대한민국
pH-sensitive graft copolymer, method of producing and polymer micelle thereof.
13/263,452.
20150714.
미국
pH-sensitive hydrogel dual ionictransition.
13/761,419 .
20141223.
미국
폴리펩타이드 기반 블록 공중합체 및 이의 제조방법, 및 이를 이용한 고분자 마이셀.
10-2012-0100072.
20141111.
대한민국
Temperature and pH-sensitive block copolymer and polymeric hydrogel using the same.
11/815,960 .
20140916.
미국
Temperature and pH-sensitive block copolymer having excellent gel strength, method of preparing the same, and drug delivery system using the same.
8102912.6 .
20140910.
EU연합
온도 및 피에이치 민감성 다중블록 공중합체 및 이의 제조방법.
10-2012-0071412 .
20140711.
대한민국
pH Sensitive block copolymer forming polyionic complex micelles and drug or protein carrier using the same.
10170584.6.
20140606.
EU연합
피에이치 민감성 폴리머좀 및 이의 제조방법.
10-2010-0112964.
20140410.
대한민국
온도 및 pH 민감성 하이드로젤의 이용한 인터벤셔널 인젝션에 기반한 간암치료용 약물전달체.
10-2011-0071184 .
20140408.
대한민국
Preparing of pH-sensitive polymersome.
2010-246854 .
20140218.
일본
Temperature and pH-sensitive block copolymer having excellent gel strengt.
12/061,322 .
20131119.
미국
pH 민감성 폴리머좀의 제조방법.
10-2010-0097500 .
20130903.
대한민국
폴리(아미도 아민)올리고머 하이드로젤 조성물 및 이를 이용한 약물전달체.
10-2010-0019215 .
20130725.
대한민국
생체접착성이 우수한 블록공중합체의 제조 및 이를 이용한 주사형 하이드로젤 약물전달체.
10-2010-0123804.
20130607.
대한민국
Temperature and pH-sensitive block copolymer having excellent gel strength, method of reparing the same, and drug delivery system using the same.
2008-96832.
20130502.
일본
수상/공훈
2003년부터 국제학회 Plenary Lecture 4회 포함 초청강연 61회, Symposium Organizer 26회 수행
2011년 이후로 Nanomedicine, NBM(IF=5.978), Advanced Healthcare Materials (IF=4.88)등 4개의 국제학술지 Editorial Board로 활동
한국연구재단 ‘2014년 기초연구사업 우수평가자’ (2015.01)
특허 등록 : 37건(국내 19건, 국제 18건)
특허 출원 : 27건(국내 10건, 국제 17건)
학술회의논문
(2016)
pH-Triggered Targeting Polymeric Nanocarriers : Theranostic Applications.
IUPAC-PSK40.
대한민국
(2016)
pH-Triggered Targeting Polymeric Nanocarriers : Theranostic Applications.
The 1st ISNM Congress.
대한민국
(2016)
Acidic-Local Targeting Polymeric Nanocarriers: Theranostic Applications.
2016 Gordon Conference on Drug Carriers in Medicine and Biology.
미국
(2016)
A novel injectable, biodegradable and pH sensitive hydrogel conjugated to human serum albumin for sustained and prolonged release of therapeutic proteins..
Warwick Polymer Conference 2016.
영국
(2016)
Stimuli sensitive block copolymer for biomedical applications.
Warwick Polymer Conference 2016.
영국
(2016)
Injectable and Stimili-Responsive Block Copolymer Hydrogels.
2016 CIMTEC.
이탈리아
(2016)
Enhancing neurogenesis and angiogenesis with target delivery of stromal cell derived factor-1a using a dual ionic pH-sensitive copolymer.
2016 CIMTEC.
이탈리아
(2016)
Poly(ethylene glycol)-poly(amino-carbonate-urethane) based pH-/temperature-sensitive, biodegradable and injectable hydrogel for protein delivery.
2016 CIMTEC.
이탈리아
(2016)
Sulfamethazine-based pH-sensitive hydrogels with potential application for transcatheter arterial chemoembolization therapy.
2016 CIMTEC.
이탈리아
(2016)
pH-responsive polymer/gold nanoparticle composite for theranostic application.
2016 CIMTEC.
이탈리아
(2016)
A novel pH-sensitive, biodegradable and injectable hydrogel based on poly(ethylene glycol)-poly(sulfamethazine-carbonate-urethane) for drug and protein delivery.
2016 춘계 고분자학회.
대한민국
(2016)
Design, Synthesis and Evaluation of Amphiphilic Block Copolymers for Biomedical Applications.
2016 춘계 한국고분자학회.
대한민국
(2016)
pH-Responsive 3D scaffold for stem cell culture.
2016 춘계 고분자학회.
대한민국
(2016)
pH-Sensitive injectable hydrogel for treatment of hepatic cancer via transarterial chemoembolization.
2nd vietnam-korea polymer materials symposium.
베트남
(2015)
Injectable polymeric hydrogels for sustained delivery of proteins.
2015 International Chemical Cogress of Pacific Basin Societies.
미국
(2015)
Injectable Block Copolymer Hydrogels For Biomedical Applications.
14th Pacific polymer Conference.
미국
(2015)
주사형 하이드로젤 및 응용.
2015 추계 한국화학공학회.
대한민국
(2015)
Injectable, Enzymatically Degradable and pH/temperature-sensitive Polycarbonate Based Hydrogel for Protein Delivery.
2015 추계 한국고분자학회.
대한민국
